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| 產(chǎn)品基本信息 |
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| 產(chǎn)品編號：O848430 |
| 產(chǎn)品名稱：(1R,?4S)?-3-?Oxo-2-?azabicyclo[2.2.1]?hept-?5-?ene-?2-?carboxylic acid 1,? |
| 產(chǎn)品CAS：151792-53-9 |
| 規(guī)格含量：5g |
| 產(chǎn)品價(jià)格：面議 |
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| 產(chǎn)品詳細(xì)介紹 |
| 標(biāo)準(zhǔn)品編號: |
O848430 |
| 名稱: |
(1R,?4S)?-3-?Oxo-2-?azabicyclo[2.2.1]?hept-?5-?ene-?2-?carboxylic acid 1,?1-?Dimethylethyl Ester |
| 別名: |
(1R,4S)-(-)-2-t-Butoxycarbonyl-2-azabicyclo[2.2.1]hept-5-en-3-one; (1R,4S)-t-Butyl 3-oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate; (1R)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic Acid 1,1-Dimethylethyl Ester |
| CAS號: |
151792-53-9 |
| 分子式: |
C??H??NO? |
| 分子量: |
209.24 |
| 類別: |
Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; |
| 應(yīng)用: |
(1R,?4S)?-3-?Oxo-2-?azabicyclo[2.2.1]?hept-?5-?ene-?2-?carboxylic acid 1,?1-?Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| 參考文獻(xiàn) |
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![(1R,?4S)?-3-?Oxo-2-?azabicyclo[2.2.1]?hept-?5-?ene-?2-?carboxylic acid 1,?](/images/defaultpic.gif "(1R,?4S)?-3-?Oxo-2-?azabicyclo[2.2.1]?hept-?5-?ene-?2-?carboxylic acid 1,?")
