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| 產(chǎn)品基本信息 |
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| 產(chǎn)品編號：T897135 |
| 產(chǎn)品名稱：Tubulysin A |
| 產(chǎn)品CAS：205304-86-5 |
| 規(guī)格含量：1mg |
| 產(chǎn)品價(jià)格：面議 |
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| 產(chǎn)品詳細(xì)介紹 |
| 標(biāo)準(zhǔn)品編號: |
T897135 |
| 名稱: |
Tubulysin A |
| 別名: |
(αS,?γR)?-γ-?[[[2-?[(1R,?3R)?-?1-?(Acetyloxy)?-?4-?methyl-?3-?[[(2S,?3S)?-?3-?methyl-?2-?[[[(2R)?-?1-?methyl-?2-?piperidinyl]?carbonyl]?amino]?-?1-?oxopentyl]?[(3-?methyl-?1-?oxobutoxy)?methyl]?amino]?pentyl]?-?4-?thiazolyl]?carbonyl]?amino]?-?4-?hydroxy-?α-?methyl-benzenepentanoic Acid; |
| CAS號: |
205304-86-5 |
| 分子式: |
C??H??N?O??S |
| 分子量: |
844.07 |
| 類別: |
Standards; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics; |
| 應(yīng)用: |
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (VIP(LA)I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range. |
| 參考文獻(xiàn) |
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