 ?您的位置：對照品 > 試劑耗材 > 生化試劑 > |
|
|
|
| 產(chǎn)品基本信息 |
|
| 產(chǎn)品編號：126654 |
| 產(chǎn)品名稱：Talarozole, ≥99% |
| 產(chǎn)品CAS：201410-53-9 |
| 規(guī)格含量：5MG |
| 產(chǎn)品價格：6300 |
| 聯(lián)系我們: |
 |
|
 |
|
|
| 產(chǎn)品詳細(xì)介紹 |
Talarozole, ≥99%
Product Name： Talarozole
CAS號:201410-53-9
分子式:C21H23N5S
分子量:377.51
貯存： 儲存溫度-20°C
可溶性： 25°C： DMSO
生化和生理學(xué)機(jī)理：
Description： IC50 Value：N/A Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne[2]. in vitro： Talarozole treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1]. in vivo： Talarozole slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the hal
|
|
|
|
|
