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| 產(chǎn)品編號：127232 |
| 產(chǎn)品名稱：PF-04447943 |
| 產(chǎn)品CAS：1082744-20-4 |
| 規(guī)格含量：5MG |
| 產(chǎn)品價格：5600 |
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| 產(chǎn)品詳細介紹 |
PF-04447943
Product Name： PF-04447943
CAS號:1082744-20-4
分子式:C20H25N7O2
分子量:395.46
貯存： 儲存溫度-20°C
可溶性： DMSO
生化和生理學機理：
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. PF-04447943 was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer's disease.
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