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| 產(chǎn)品基本信息 |
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| 產(chǎn)品編號：128082 |
| 產(chǎn)品名稱：QL-IX-55 |
| 產(chǎn)品CAS：1223002-54-7 |
| 規(guī)格含量：5MG |
| 產(chǎn)品價格：8000 |
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| 產(chǎn)品詳細介紹 |
QL-IX-55
Product Name： QL-IX-55
CAS號:1223002-54-7
分子式:C24H14F4N4O
分子量:450.39貯存： 儲存溫度-20°C
可溶性： DMSO
生化和生理學機理：
The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast.
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